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Recent Publications

Eker A, Fahrioglu U, Serakinci N. (2015) A late onset tremor and ataxia syndrome; FXTAS and it's ignored peripheral nervous system findings in diagnostic criteria. Arch Neuropsychiatr, [Epub ahead of print].

Becer E, Çırakoglu A. (2015) Association of the Ala16Val MnSOD gene polymorphism with plasma leptin levels and oxidative stress biomarkers in obese patients. Gene, [Epub ahead of print].

Kalkan R, Atli Eİ, Özdemir M, Çiftçi E, Aydin HE, Artan S, Arslantaş A. (2015) IDH1 mutations is prognostic marker for primary glioblastoma multiforme but MGMT hypermethylation is not prognostic for primary glioblastoma multiforme. Gene, 554(1):81-6.

Tulay P, Gultomruk M, Findikli N, Bahceci M. (2015) Number of embryos biopsied as a predictive indicator for the outcome of preimplantation genetic diagnosis by fluorescence in situ hybridisation in translocation cases. Zygote, [Epub ahead of print].

Atli EA, Kalkan R, Ciftci E, Ozkara E, Cilingir O, Ozdemir M, Ozbek Z, Artan S, Arslantas A. (2014) IDH2 mutations in a Turkey series of Primary Glioblastoma. Journal of Neurological Sciences, 31(4):693-698.

Tulay P, Gultomruk M, Findikli N, Bahceci M. (2014) Poor embryo development and preimplantation genetic diagnosis outcomes of translocations involving chromosome 10: Do we blame genetics? Zygote, [Epub ahead of print].

Tulay P, Gultomruk M, Findikli N, Yagmur E, Bahceci M. (2014) Is the interchromosomal effect present in embryos derived from Robertsonian and reciprocal translocation carriers particularly focusing on chromosome 10 rearrangements? Zygote, [Epub ahead of print].

Ozden S, Tiber P, Ozgen Z, Ozyurt H, Serakinci N, Orun O. (2014) Expression of TRF2 andits prognostic relevance in advanced stage cervical cancer patients. Biol Res, 47(1):61.

Teralı K, Zorlu T, Bulbul O, Gurkan C. (2014) Population genetics of 17 Y-STR markers in Turkish Cypriots from Cyprus, Forensic Science International: Genetics, 10:e1-e3.

Becer E, Mehmetçik G, Bareke H, Serakıncı N. (2013) Association of leptin receptor gene Q223R polymorphism on lipi profiles in comparison study between obese and non-obese subjects. Gene, 529(1):16-20.

Serakinci N, Fahrioglu U, Christensen R. Mesenchymal stem cells, cancer challenges and new directions.
Eur J Cancer. 2014 Mar 7. pii: S0959-8049(14)00173-7. doi: 10.1016/j.ejca.2014.02.011. [Epub ahead of print] Review.
PMID: 24613620 [PubMed - as supplied by publisher]

BecerE, Mehmetçik G, Bareke H, Serakıncı N. Association of leptin receptor gene Q223R polymorphism on lipi profiles in comparison study between obese and non-obese subjects. Gene xxx (2013) xxx-xxx
Harbo M, Koelvraa S, Serakinci N, Bendix L.Telomere dynamics in human mesenchymal stem cells after exposure to acute oxidative stress. DNA Repair (Amst). 2012 Sep 1;11(9):774-9. doi: 10.1016/j.dnarep.2012.06.003. Epub 2012 Jul 9

Nedime Serakinci1,2, Rikke Christensen3,4, Umut Fahrioglu2, Flemming Brandt Sorensen5, Frederik Dagnæs-Hansen6, Miroslav Hajek1, Tinna Herløv Jensen5, Steen Kolvraa7, Nicol W Keith: Mesenchymal stem cells as therapeutic delivery vehicles targeting tumor stroma, Cancer Biotherapy& Radiopharmaceuticals, 2011 Aug 30

Sevgi A.Ozden1, Hazan Ozyurt1, Zerrin Ozgen2, Olca Kilinc3, Mustafa Oncel4, Aylin Gul5, Nimet Karadayi5, Nedime Serakinci6, Beki Kan7, Oya Orun3, Association of Sensitive-to-Apoptosis Gene (SAG) Expression with Radiosensitivity to Radio/Chemotherapy in Advanced Rectal Cancers,World Journal of Gastroenterology, 2011, November 28; 17(44): 4905-4910.

BecerE, Mehmetçik G, Bareke H, Serakıncı N. Association of leptin receptor gene Q223R polymorphism on lipi profiles in comparison study between obese and non-obese subjects. Gene xxx (2013) xxx-xxx

Previous Publications

Kyle Lafferty-Whyte1, Claire J. Cairney1, Malcolm B. Will1, Nedime Serakinci3, Maria-Grazia Daidone2, Nadia Zaffaroni2 and W. Nicol Keith1, A gene expression signature classifying telomerase and ALT immortalisation reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT, Oncogene, 2009 Oct 29;28(43):3765-74. Epub 2009 Aug 17

Öngören Şeniz, Tarkan-Argüden Yelda , Ar M. Cem,Yılmaz Şükriye, Üre Ümit, Kuru Dilhan, Eşkazan Ahmet Emre, Güven Gülgün S., Çetin Güven, Çırakoğlu, Ayşe, Başlar Zafer, Deviren Ayhan, Aydın Yıldız, Hacihanefioğlu Seniha, Ferhanoğlu Burhan, Tüzüner Nükhet, Ülkü Birsen, Soysal Teoman. Clonal Chromosomal Abnormalities In Philadelphia-Negative Cells And Their Clinical Significance In Patients With Chronic Myeloid Leukemia: Results Of A Single Center. Türkiye Klinikleri Tıp Bilimleri Dergisi 2009;29(2):321-30.

Tarkan-Argüden Y., Ar M. C., Yılmaz Ş., Öngoren Ş., Kuru D., Üre Ü., Çırakoglu A., Eşkazan A. E., Güven G. S., Çetin G., Purisa S., Baslar Z., Deviren A., Aydın Y., Hacıhanefioglu S., Ferhanoglu B., Tüzüner N., Ülkü B., Soysal T. “Cytogenetic clonal evolution in patients with chronic myeloid leukemia” Biotechnol. & Biotechnol. Eq., 23(4): 1515-20 (2009).

DOI: 10.2478/v10133-009-0022-6 Cytogenetic clonal evolution in patients with chronic myeloid leukemia
Rikke Christensen, Jan Alsner, Flemming Brandt Sorensen, Frederik Dagnaes-Hansen, Steen Kolvraa, Nedime Serakinci: Transformation of human mesenchymal stem cells in radiation carcinogenesis; Long-term effect of ionizing radiation, Regen Med. 2008 Nov;3(6):849-61

Nedime Serakinci,, Jesper Graakjær, Steen Kolvraa: Telomere stability and telomerase in mesenchymal stem cells, Reiew article, Biochimie. 2008 Jan;90(1):33-40. Epub 2007 Sep 25.

Ayşe Çırakoğlu, Yelda Tarkan-Argüden, Ayhan Deviren, Dilhan Kuru, Şükriye Yılmaz, Su Gülsün Berrak, Cengiz Canpolat, Seniha Hacıhanefioğlu. A childhood acute lymphoblastic leukemia (ALL) case with t(3;17)(q23;p13),t(5;12)(q31;p13),inv(11) (p15q12). t(3;17)(q23;p13),t(5;12)(q31;p13),inv(11)(p15q12)’li bir çocukluk çağı akut lenfoblastik lösemi (ALL) olgusu. Turk J Hematol 2008; 25: 152-4. (Case report)
Fahrioglu U, Murphy MW, Zarkower D, Bardwell VJ. “mRNA expression analysis and the molecular basis of neonatal testis defect in Dmrt1 mutant mice” Journal of Sexual Development 2007;1:42-58.

Nedime Serakinci & Can Erzik: Rod for understnding cancer stem cells: model cell lines. Review article, Regen Med 2007, Nov 2(6),957-965.

E. Yosunkaya-Fenerci, G. S. Güven, D. Kuru, Ş.Yılmaz, Y. Tarkan-Argüden, A. Çırakoğlu, A.Deviren, A. Yüksel, S. Hacıhanefioğlu. Supernumerary chromosome der(22)t(11;22): Emanuel sydrome associates with novel features. Genetic Counseling, 18(4):401-8, 2007

Jesper Graakjær, Rikke Christensen, Steen Kølvraa, Nedime Serakinci: Mesenchymal stem cells with high telomerase expression do not actively restore their chromosome arm specific telomere length pattern after exposure to ionizing radiation. BMC Mol Biol. 2007 Jun 13;8(1):49 [Epub ahead of print]

Nedime Serakinci, Rikke Christensen, Jesper Graakjær, Claire J. Anderson, W. Nicol Keith, Jan Alsner, Gabriele Saretzki, Steen Kolvraa : Immortalized adult human mesenchymal stem cells are less radiosensitive than their mortal counterpar, Exp Cell Res. 2007 Mar 10;313(5):1056-67. Epub 2007 Jan 8

Serakinci N, Keith WN: Therapeutic potential of adult stem cells. Eur J Cancer. 42; 1243-1246, 2006

Nedime Serakinci, Stacey F. Hoare, Moustapha Kassem, Stuart P. Atkinson, and W. Nicol Keith: Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell, Regenerative Med. 1 (1), 125-131, 2006

Palanduz S, Serakinci N, Cefle K, Aktan M, Tutkan G, Ozturk S, Bozkurt G, Dincol G, Pekcelen Y, Koch J.A different approach to telomere analysis with ddPRINS in chronic lymphocytic leukemia. Eur J Med Genet. 2006 Jan-Feb;49(1):63-9. Epub 2005 Feb 1.

W. Nicol Keith, Tom Vulliamy, Jiangqin Zhao, Can Erzik, Alan Bilsland, Cem Ar, Birsen Ulku, Anna Marrone, Philip J Mason*, Monica Bessler, Nedime Serakinci and Inderjeet Dokal, A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria, BMC Blood Disord. 4(1): 3, 22 Jun 2004

Serakinci N, Guldberg P, Burns J, Abdallah B, Shrødder H, Jensen T, and Kassem M The adult human mesenchymal stem cell as a target for neoplastic transformation, Oncogene, 23(29): 5095-5099, 2004 (Awarded with an editorial commentary).

Serakıncı N, Ostergaard M, Larsen H, Madsen B, Pedersen B, Koch J,: Multiple chromosome end aberrations in a telomerase positive leukemia patient. Cancer Genet. Cytogenet 138,11-16, 2002.

Serakıncı N, and Koch J,: Telomerase activity in human leukemic cells with or without monosomy 7 or 7q-. BMC Medical Genetics 3, 11, 2002.

Simonsen JL, Rosada C, Serakinci N, Justesen J, Stenderup K, Rattan SI, Jensen TG and Kassem M Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nature Biotech 20, 592-596, 2002.

Serakıncı N, Pedersen B, Koch J,: Expansion of repetitive DNA into cytogenetically visible elements, Cytogenet. Cell Genet 92, 182-185, 2001.

Palanduz S, Ozturk S, Cefle K, Karaman B, Tutkan G, Ustek D, Ucur A, Serakıncı N, Basaran S. A case of Turner syndrome with a rare reciprocal translocation between an autosome and the X chromosome. BJMG 3, 45-48, 2000.

Sukru Ozturk, Sukru Palanduz, Melih Aktan, Kivanc Cefle, Nedime Serakıncı, Yuksel Pekcelen: Sister chromatid exchange frequency in B-cells stimulated by TPA in chronic lymphocytic leukemia. Cancer Genet. Cytogenet 123, 49-51, 2000.

Palanduz S, Ozturk S, Cefle K, Tutkan G, Karaman B, Ustek D, Ucur A, Serakıncı N, Basaran S. A case of mental retardation associated with a partial tetrasomy of chromosome 15. BJMG, Vol:3(1), 45-48, 2000.

Serakıncı N, Koch J,: Telomeric repeats of immortal hamster cells, Turk J Med Sci 30, 315-320, 2000.

Palanduz S., Berkman Z., Çefle K., Öztürk S, Serakıncı N., Akif Karan M., Tas F.,: A family with several members affected by brain tumours, skin lesions and renal involvement Tuberous Sclerosis, Medical Bulletin of Istanbul Medical Faculty, 33:1, 62-67, 2000.
Serakıncı N, Krejci K, Koch J,: Telomeric repeat organization- a comparative in situ study between man and rodent, Cytogenet. Cell Genet. 86, 204-211, 1999.
Serakıncı N, Koch J: Detection and sizing of telomeric repeat DNA In Situ. Nature Biotech. 17, 200-201, 1999.

Palanduz S., Çefle K., Öztürk S., Karan MA, Tas F., Serakıncı N.: A Family with Von Hippel-Lindau disease with several members affected by renal involvement and brain tumors, Medical Bulletin of Istanbul Medical Faculty, 32:1, p8992, 1999.

Serakıncı N,: Investigation on the Relationship of Telomeres with Cancer and Aging by using advanced Molecular Cytogenetic Techniques, Health Science Institute Department of Medical Genetics and Biology, Brief report, Turk J Med Sci, p9882, 1999.
Serakıncı N,:Variations of chromosome heteromorphism in early recurrent abortions and significance of especially Y- chromosome heteromorphism, Istanbul University, Health Science Institute Department of Medical Genetics, Medical Bulletin of Istanbul Medical Faculty, p687, 1993.

Book Chapters

Culture of Animal Cells, 5th ed. Author: R.I. Freshney; Chapter No: 17 Copyright © 2005 Wiley[Imprint], Inc

Essay in Encyclopedia of Cancer. Springer-Verlag Berlin and Heidelberg GmbH & Co. K, Berlin, UK, 2nd edition 2008.

Molecular cytogenetic applications in diagnostics and research - an overview Nedime Serakinci1,2 & Steen Koelvraa2,* Springer-book

Culture of Animal Cells, 6th ed. Author: R.I. Freshney; Copyright © 2005 Wiley[Imprint], Inc October 2010.

Cancer Stem Cells, In Tech, Editor: Niksa Mandic ISBN nr. 978-953-307-225-8

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